RT Journal Article
SR Electronic
T1 Abstract A104: Leptin and leptin receptor genes in relation to premenopausal breast cancer incidence and grade in Caucasian women
JF Cancer Prevention Research
JO Cancer Prev Res (Phila)
FD American Association for Cancer Research
SP A104
OP A104
DO 10.1158/1940-6207.PREV-11-A104
VO 4
IS 10 Supplement
A1 Gu, Fangyi
A1 Kraft, Peter
A1 Rice, Megan
A1 Michels, Karin B.
YR 2011
UL http://cancerpreventionresearch.aacrjournals.org/content/4/10_Supplement/A104.abstract
AB Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MABackground: Body mass is inversely related to breast cancer risk among premenopausal women. Leptin, an essential cytokine regulating food intake, energy expenditure, glucose and fat metabolism may be part of the mechanistic pathway.Methods: We investigated 50 tagging and candidate SNPs in the leptin (LEP) and leptin receptor (LEPR) genes, for associations with premenopausal breast cancer incidence using 405 cases and 810 controls nested within the Nurses' Health Study II. We also examined associations between these SNPs and circulating leptin (among 910 women) and breast cancer grade (among 267 patients). Permutation tests were performed to adjust for multiple testing.Results: We did not detect a significant association between SNPs in the LEP or LEPR gene and either breast cancer incidence or plasma leptin levels. However, among cases, 14 SNPs of the LEPR gene were significantly associated with cancer grade, and rs1137101 (Q223R) survived multiple testing adjustment (adjusted p=0.04). The G carriers of rs1137101 were more likely to have poorly differentiated than well differentiated cancers. Conclusions: Our data suggest that common genetic variation in the LEP or LEPR gene has no strong association with premenopausal breast cancer risk. The LEPR gene might be associated with breast cancer grade.Citation Information: Cancer Prev Res 2011;4(10 Suppl):A104.