PT - JOURNAL ARTICLE AU - Greenlee, Heather AU - Shi, Zaixing AU - Hibshoosh, Hanina AU - Giri, Dilip D. AU - Ahmed, Aqeel AU - Williams, Samantha AU - Falcone, Domenick J. AU - Winston, Lisle A. AU - Zhou, Xi K. AU - Hudis, Clifford A. AU - Hershman, Dawn L. AU - Dannenberg, Andrew J. AU - Iyengar, Neil M. TI - Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients AID - 10.1158/1940-6207.CAPR-18-0207 DP - 2019 Jan 01 TA - Cancer Prevention Research PG - 21--30 VI - 12 IP - 1 4099 - http://cancerpreventionresearch.aacrjournals.org/content/12/1/21.short 4100 - http://cancerpreventionresearch.aacrjournals.org/content/12/1/21.full SO - Cancer Prev Res (Phila)2019 Jan 01; 12 AB - Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm2. Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5–<25.0 kg/m2), overweight (25.0–<30.0 kg/m2), class I obesity (30.0–<35.0 kg/m2), and class II–III obesity (35.0 kg/m2 or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36–96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II–III obesity; Ptrend <0.01). Severe BWATi (>0.27 CLS-B/cm2) was associated with higher BMI (Ptrend = 0.046) and greater adipocyte diameter (P = 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all P < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.