PT  - JOURNAL ARTICLE
AU  - Greenlee, Heather
AU  - Shi, Zaixing
AU  - Hibshoosh, Hanina
AU  - Giri, Dilip D.
AU  - Ahmed, Aqeel
AU  - Williams, Samantha
AU  - Falcone, Domenick J.
AU  - Winston, Lisle A.
AU  - Zhou, Xi K.
AU  - Hudis, Clifford A.
AU  - Hershman, Dawn L.
AU  - Dannenberg, Andrew J.
AU  - Iyengar, Neil M.
TI  - Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients
AID  - 10.1158/1940-6207.CAPR-18-0207
DP  - 2019 Jan 01
TA  - Cancer Prevention Research
PG  - 21--30
VI  - 12
IP  - 1
4099  - http://cancerpreventionresearch.aacrjournals.org/content/12/1/21.short
4100  - http://cancerpreventionresearch.aacrjournals.org/content/12/1/21.full
SO  - Cancer Prev Res (Phila)2019 Jan 01; 12
AB  - Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm2. Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5–<25.0 kg/m2), overweight (25.0–<30.0 kg/m2), class I obesity (30.0–<35.0 kg/m2), and class II–III obesity (35.0 kg/m2 or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36–96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II–III obesity; Ptrend <0.01). Severe BWATi (>0.27 CLS-B/cm2) was associated with higher BMI (Ptrend = 0.046) and greater adipocyte diameter (P = 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all P < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.