Table 2.

Baseline rectal ACFs by trial participation status

All registered (n = 129)Ineligible or withdrawn (n = 44)Intervention cohort (n = 85)Pa
ACF number, total998127871
ACF number, per subjectb<0.001
 Median (range)7 (0–34)2 (0–12)9 (5–34)
Crypts per ACF, n (%)0.97
 5–9178 (17.8)22 (17.3)156 (17.9)
 10–19345 (34.6)43 (33.9)302 (34.7)
 ≥20475 (47.6)62 (48.8)413 (47.4)
Lumen shape, n (%)0.005
 Irregular138 (13.8)15 (11.8)123 (14.1)
 Mixed101 (10.1)26 (20.5)75 (8.6)
 Normal15 (1.5)3 (2.4)12 (1.4)
 Oval/round609 (61.0)70 (55.1)539 (61.9)
 Slit-like132 (13.2)13 (10.2)119 (13.7)
 Otherc3 (0.3)0 (0.0)3 (0.3)
Maximum diameter, mm20.09
 Median (range)1.0 (0.1–10.0)1.0 (0.3–4.0)1.0 (0.1–10.0)
Tissue plane, n (%)d<0.001
 Depressed2 (0.2)1 (0.8)1 (0.1)
 Flat575 (57.6)53 (41.7)522 (59.9)
 Elevated421 (42.2)73 (57.5)348 (40.0)
Staining intensity, n (%)d<0.001
 Equal336 (33.7)50 (39.4)286 (32.8)
 Lighter122 (12.2)27 (21.3)95 (10.9)
 Darker540 (54.1)50 (39.4)490 (56.3)
  • aP value for comparison between ineligible or withdrawn subjects versus intervention cohort subjects using Fisher's exact test for categorical responses and rank-sum test for continuous responses.

  • bMedian (range).

  • cIndistinct (n = 1) or unknown (n = 2).

  • dRelative to the surrounding rectal mucosa.