Table 4.

Change in rectal ACF number by randomization arm

Overall (n = 77)Atorvastatin (n = 20)Sulindac (n = 18)ORAFTI®Synergy1 (n = 20)Control (n = 19)
Baseline
 Median9.09.09.58.59.0
 Range5–345–245–345–286–17
 Mean10.310.111.110.29.7
 SD5.25.06.95.53.1
Postintervention
 Median8.08.07.58.58.0
 Range0–413–411–271–340–20
 Mean9.911.09.910.38.5
 SD7.68.68.08.74.9
% Changea
 Median−7.15.6−18.6−3.6−10.0
 Range−100 to 160−69 to 143−83 to 160−88 to 83−100 to 117
 Mean−5.38.4−13.3−8.8−8.6
 SD50.349.155.449.248.8
Pbn/a0.300.600.92n/a
Pc0.200.590.120.540.41
  • a(Postintervention ACF number − baseline ACF number)/Baseline ACF number.

  • bWilcoxon rank-sum P value for comparison of % change in ACF between each active intervention (atorvastatin, sulindac, or ORAFTI®Synergy1) versus control.

  • cSigned rank P value for comparison of percentage change in ACF within each randomization arm.