Table 1.

The effect of P-S, DFMO, or P-S/DFMO on molecular targets in colon cancer xenografts

Molecular targetsP-SDFMOP-S/DFMO
Polyamines
Putrescine↓ 13%, n.s.↓ 82%, P < 0.01↓ 88%, P < 0.01
Spermidine↓ 8%, n.s.↓ 43%, P < 0.03↓ 61%, P < 0.03
Spermine↓ 3%, n.s.↑ 10%, n.s.↑ 4%, n.s.
COX-2↓ 31%, n.s.↓ 20%, n.s.↓ 42%, P < 0.03
NF-κB↑ 4%, n.s.↓ 14%, n.s.↓ 6%, n.s.
Trx-1↓ 50%, P < 0.02↓ 8%, n.s.↓ 50%, P < 0.01
TrxR↓ 60%, P < 0.01↓ 40%, P < 0.01↓ 63%, P < 0.01
Tumor inhibition65.9%, P < 0.0152.9%, P < 0.0170.9%, P < 0.01

NOTE: All comparisons are to the control group.

Abbreviation: n.s., not significant.