Table 2.

Comparison of gene expression changes presented as fold changes

SymbolCategory and definitionCC-LR/WTWT + NTHi/WTCC-LR + NTHi/CC-LRWT + OVA/WTCC-LR+OVA/CC-LRAccession Number
Inflammatory
Il1bInterleukin 1 beta146.80218.54.959.10.90NM_008361
Il6Interleukin 617.0014.61.6−5.9-3.90NM_031168.1
Il12bInterleukin 12 beta87.0012.7−9.0−12.5-50.30NM_008352.2
Il17fInterleukin 17f7.4017.61.1−0.02-10.50NM_145856.1
Il18Inteleukin 182.601.63.60.21.20NM_008360.1
TNFTumor necrosis factor17.5051.23.1−19-7.20NM_144548.1
Il17raInterleukin 17 receptor A1.101.73.30.70.05NM_013693.1
Il8rbInterleukin 8 receptor, beta27.20244.50.8-2.20NM_008359.1
Cxcl2Chemokine (C-C motif) receptor 239.9033.62.5−0.9-0.60NM_009909.3
Cxcr4Chemokine (C-X-C motif) receptor 4238.80157.51.419.7-0.06NM_009915.1
Cxcl4Chemokine (C-X-C motif) ligand 41.600.72.91.30.46NM_009140.2
Ifngr1Interferon gamma receptor 12.202.71.80.91.10NM_009911.2
Ifngr2Interferon gamma receptor 21.304.11.61.50.80NM_019932.2
Ifi30Interferon gamma inducible protein 302.603.52.21.31.03NM_010511.2
Immune response
Nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells, 1 p1051.602.41.41.20.51NM_008689.2
Nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B cells 279.7040.91.531.50.07NM_019408.1
Stat3Signal transducer and activator of transcription 32.503.51.90.70.30NM_011486.4
Ap1m2Adaptor protein complex AP-1, mu 2 subunit6.8044.81.80.30.40NM_009678.1
Tlr2Toll-like receptor 2381.50250.73.34.40.80NM_011905.2
Tlr4Toll-like receptor 413.6014.41.5−0.70.60NM_021297.2
Tlr6Toll-like receptor 681.7045.61.2−1.80.26NM_011604.2
Tlr7Toll-like receptor 721.307.11.85.70.89NM_133211.3
Irak2Interleukin-1 receptor–associated kinase 22.401.91.70.70.37NM_172161.2
Raet1aRetinoic acid early transcript 1, alpha9.1012.10.1−5.2−3.70NM_009016.1
S100a8S100 calcium-binding protein A82.202.12.11.60.80NM_013650.2
Kng1Kininogen 13.6017.22.22.31.70NM_023125.2
Kng2Kininogen 28.502.25.60.80.70NM_201375.1
LbpLipopolysaccharide binding protein3.301.31.30.40.50NM_008489.2
Cd68CD68 antigen54.907.11.46.31.10NM_009853.1
Cell cycle and growth
Fgf7Fibroblast growth factor 72.602.61.20.5−1.60NM_008008.3
MycMyelocytomatosis oncogene12.005.51.3−53.30NM_010849.4
EregEpiregulin5.705.92.3−6.9−4.80NM_007950.1
Cdkn2aCyclin-dependent kinase inhibitor 2A17.9018.91.1−3.3−2.60NM_009877.2
Fgfr2Fibroblast growth factor receptor 220.0016.45.50.72.20NM_010207.2
Itm2bIntegral membrane protein 2B1.901.81.2−1.750.51NM_008410.2
Csf1rColony-stimulating factor 1 receptor13.9016.12.31.72.60NM_001037859.2
Csf2Colony-stimulating factor 2244.5041.62.07.50.40NM_009969.4
Csf2raColony-stimulating factor 2 receptor, alpha354.40150.31.240.30.20NM_009970.1
Socs3Suppressor of cytokine signaling 32.701.61.11.40.90NM_007707.2
Cdkn1aCyclin-dependent kinase inhibitor 1A5.903.41.74.11.10NM_007669.2
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 114.7075.22.119.21.10NM_010130.1
AregAmphiregulin9.901.61.21.10.80NM_009704.3
Cell death and apoptosis
CidebCell death–inducing DNA fragmentation factor, alpha subunit-like effector B67.4021.51.4−2.70.60NM_009894.2
Bcl2l14Bcl2-like protein1429.7030.21.5−25.6−4.00NM_025778.1
Bcl2a1cB-cell leukemia/lymphoma 2–related protein A1c233.0042.62.5−0.10.07NM_007535.2
Angiogenesis, invasion, and metastasis
PdgfcPlatelet-derived growth factor, C polypeptide29.4018.31.89.41.20NM_019971.2
VegfcVascular endothelial growth factor C2.302.71.42.11.60NM_009506.2
HbegfHeparin-binding EGF-like growth factor1.101.11.51.62.10NM_010415.1
Hif1aHypoxia inducible factor 1, alpha subunit23.6017.46.6−41.7−6.50NM_010431.1
Icam1Intercellular adhesion molecule 16.804.53.42.10.80NM_010493.2
Pecam1Platelet/endothelial cell adhesion molecule 11.903.11.90.60.50NM_008816.2
Mmp2Matrix metallopeptidase 21.403.31.20.30.30NM_008610.2
Mmp12Matrix metallopeptidase 122,827.00305.55.0299.40.40NM_008605.3
Mmp14Matrix metallopeptidase 141.902.91.31.90.40NM_008608.2
Timp1Tissue inhibitor of metalloproteinase 19.3017.41.42.41.20NM_011593
Nus1Nuclear undecaprenyl pyrophosphate synthase 1 homologue301.2072.51.411.60.40NM_030250.1
AngAngiogenin2.501.91.50.80.70NM_007447.2
Tgfbr1Transforming growth factor, beta receptor I3.404.91.50.90.70NM_009370.2
Tgfbr2Transforming growth factor, beta receptor II2.402.22.20.50.90NM_009371.2
Lcn2Lipocalin 29.7015.42.17.20.80NM_008491.1
Protein synthesis, turnover, and targeting
Eif1aEukaryotic translation initiation factor 1A1.901.31.10.70.62NM_025437.4
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue2.300.31.10.50.70NM_021284.4
Hras1Harvey rat sarcoma virus oncogene 11.801.91.21.8−0.08NM_008284.1
Nola2Nucleolar protein family A, member 22.101.81.80.80.50NM_026631.3
Nol5ANucleolar protein 5A56.707.62.3−1.8−0.57NM_024193.2
Nup62Nucleoporin 622.901.51.11.10.72NM_053074.1
Rasl11aRAS-like, family 11, member A5.302.41.930.58NM_026864.1
RhogRas homologue gene family, member G1.500.91.31.61.36NM_019566.3
CtscCathepsin C9.107.81.72.90.87NM_009982.2
Sdcbp2Syndecan-binding protein2.409.316.80.2-0.48NM_001098227.1
Morphogenesis
Krt19Keratin 1926.3018.11.215.70.55NM_008471.2
Krt23Keratin 233.601.31.30.70.70NM_033373.1
Lamc2Laminin, gamma 230.1067.21.9−13.7−0.50NM_008485.3
SftpbSurfactant-associated protein B3.401.31.50.90.40NM_147779.1
Transcription and chromatin structure
Bhlhb8Basic helix-loop-helix domain containing, class B, 82.101.41.71.12.10NM_010800.3
Ddx39DEAD (Asp-Glu-Ala-Asp) box polypeptide 3919.9016.51.15.80.66NM_197982.2
LmnaLamin A9.105.81.120.80NM_019390.1
PpargPeroxisome proliferator-activated receptor gamma18.6012.72.81.11.60NM_011146.2
SpibSpi-B transcription factor (Spi-1/PU.1-related)18.4035.91.013−4.80NM_019866.1