Table 1.

Results of SphK1 deficiency on 4-NQO–induced tongue carcinogenesis

Squamous cell carcinomas in Tongues
IncidenceMultiplicityVolume
Wild type26/27 (96%)2.11 ± 0.2327.02 ± 7.45
SphK1 KO18/25 (72%)*1.20 ± 0.19**4.85 ± 1.74***

Multiplicity and volume values are mean ± SE.

Significantly different from wild-type mice by χ2 test (*P < 0.05).

Significantly different from wild-type mice by Student t-test (**P < 0.01 and ***P < 0.05).