Table 1.

Effects of CDB-4142 on animal body weight at the end of experiment

StudyTreatment (months)Dose (mg/kg)nMean body weight (g)P
ToxicityGavagestudy end
 123.5016489
 223.52016461ns
 323.57022476ns
 423.520022420a0.1
PreventionPelletsExamined
 13020253
 23320247ns
 333020245ns

NOTE: In toxicity study the animals' weight was monitored for 23.5 months whereas in cancer prevention study animals were sacrificed 3 months after i.p. injection of animals with MNU.

Abbreviation: ns, not significant.

  • aIn the long-term experiment, the high dose of CDB-4124 (200 mg/kg) slightly decreased the body weight but the difference with control group was not significant (P < 0.1).