Table 1.

Multivariate linear regression analysis for prediction estrogen receptor (ER) mean percent staining and intensity in atypical hyperplasia

Mean ER Percent stainingMean ER Intensity
N (%)(95% CI)*P-value*(95% CI)*P-value*
Age
<4532 (13.0)38 (27–50)0.01145 (29–62)0.008
45–5484 (34.1)38 (30–46)48 (36–59)
55+130 (52.8)48 (40–56)61 (50–73)
Indication for biopsy
Lump93 (38.1)42 (33–50)0.70652 (40–64)0.868
Mammogram151 (61.9)41 (32–49)51 (39–63)
Type of atypia
ADH87 (35.4)56 (47–65)<0.00179 (66–92)<0.001
ALH141 (57.3)28 (21–36)30 (20–41)
Both18 (7.3)39 (27–52)46 (28–63)
Number of foci
1132 (53.7)39 (31–47)0.58447 (36–59)0.374
268 (27.6)43 (34–51)53 (41–66)
3+46 (18.7)42 (31–53)54 (39–69)
Involution
None18 (7.5)34 (22–47)0.27744 (27–62)0.378
Partial188 (78.7)43 (36–50)52 (41–62)
Complete33 (13.8)46 (35–57)58 (42–74)
Family history
None136 (58.1)42 (35–50)0.89952 (41–62)0.993
Weak43 (18.4)41 (3–51)52 (37–66)
Strong55 (23.5)41 (3–50)51 (38–65)

* Least squares means and P values, adjusting for age, indication for biopsy, type of atypia, number of foci, involution, and family history