Table 3.

Effect of selenomethionine on food intake and on extraprostatic tumor development in 17β-estradiol plus testosterone–treated NBL rats

Group123
Selenomethionine dose (as selenium-mg/kg diet)01.53
Effective no. of animals303030
Food intake (g/wk; mean ± SD)     4 wk132 ± 12.7138 ± 6.1143 ± 5.6*
    8 wk140 ± 3.2143 ± 10.0144 ± 4.9
    24 wk132 ± 12.7134 ± 8.0137 ± 3.1
Lesion incidenceNo. (%) of rats with lesion
Pituitary tumors30 (100)30 (100)30 (100)
Mammary adenocarcinomas
    Total mammary cancer incidence8 (27)3 (10)5 (17)
        Tubulo-papillary carcinomas5 (17)2 (7)4 (14)
        Compact/cribriform-comedo carcinomas3 (10)1 (3)1 (3)
Other tumors
    Thymic lymphoma3 (10)1 (3)3 (10)
    Localized lymphoma of lymph nodes1 (3)1 (3)2 (7)
    Skin: squamous papilloma01 (3)0
    Adrenal pheochromocytoma2 (7)1 (3)1 (3)
  • *P < 0.01 for difference with control group (ANOVA with Dunnett's multiple comparison test).