Table 5.

Effect of α-tocopherol on extraprostatic tumor development in 17β-estradiol plus testosterone–treated NBL rats

Group123
α-Tocopherol acetate dose (mg/kg diet)02,0004,000
Effective no. of animals303030
Lesion incidenceNo. (%) of rats with lesion
Pituitary tumors30 (100)30 (100)30 (100)
Mammary adenocarcinoma
    Total cancer incidence1 (3)*8 (27)*,7 (23)*,
        Tubulo-papillary carcinomas05 (17)5 (17)§
        Compact tubular carcinomas1 (3)1 (3)1 (3)
        Cribriform carcinomas02 (7)2 (7)§
Other tumors
    Mammary fibroadenoma001 (3)
    Thymic lymphoma2 (7)2 (7)2 (7)
    Localized lymphoma of lymph nodes2 (7)2 (7)1 (3)
    Adrenal pheochromocytoma1 (3)2 (7)0
    Abdominal mesothelioma2 (7)00

NOTE: Data were tested for significance using the Fisher's exact test and for linear trend with dose using a 2 × 3 χ2 test. Differences were considered statistically significant at P ≤ 0.05 (two sided for Fisher's exact test).

  • *P = 0.0381; Ptrend = 0.0428 (2 × 3 χ2 test).

  • P = 0.0257 for difference with control group (two-sided Fisher's exact test).

  • P = 0.0523 for difference with control group (two-sided Fisher's exact test).

  • §One animal had both a tubulo-papillary and a cribriform carcinoma.