Table 2.

Abnormalities in selected and pooled FISH aneuploidy markers among nested incident lung cancer cases and controls sampled from the Colorado High-Risk Cohort

MarkerCases* (n = 100)Controls* (n = 96)OR (95% CI)
AbnormalAbnormalAge-adjusted modelFully adjusted model*
n (%)n (%)
Individual DNA markers
    EGFR59 (59)21 (22)5.2 (2.8-9.8)4.9 (2.6-9.4)
    5p1547 (47)13 (14)5.7 (2.8-11.5)5.6 (2.7-11.4)
    MYC46 (46)12 (13)6.0 (2.9-12.4)5.5 (2.6-11.5)
    CEP 619 (19)2 (2)11.1 (2.5-49.0)12.0 (2.7-54.5)
No. of abnormal markers among the pooled four
    None31 (31)67 (70)1.0 (reference)1.0 (reference)
    Any of the four69 (69)29 (33)5.2 (2.8-9.4)5.0 (2.6-9.3)
    ≥2 markers56 (56)14 (15)8.8 (4.2-18.2)8.3 (3.9,17.7)

Abbreviation: 95% CI, 95% confidence interval.

  • *Adjusted for age, sex, FEV1, pack-years of smoking, and current smoking status.