Table 4.

Prediction of prostate cancer: univariate and multivariable analyses of rs198977, hK2 level, and the interaction between rs198977 and hK2 level

CAPS1 (707 controls, 189 cases)CAPS2 (893 controls, 143 cases)CAPS1 + CAPS2 (1,600 controls, 332 cases)
OR (95% CI)POR (95% CI)POR (95% CI)P
Univariate
    Any T allele*1.48 (1.07-2.04)0.0181.15 (0.81-1.64)0.41.29 (1.02-1.64)0.034
Controlling for hK2
    Any T allele*3.10 (2.11-4.55)<0.00052.07 (1.38-3.09)<0.00052.55 (1.94-3.37)<0.0005
    Log hK23.24 (2.57-4.08)<0.00053.63 (2.82-4.67)<0.00053.43 (2.90-4.07)<0.0005
Interaction analysis
    Any T allele*0.34 (0.10-1.19)0.0910.20 (0.05-0.82)0.0250.27 (0.11-0.68)0.005
    Interaction0.43 (0.27-0.69)<0.00050.41 (0.24-0.69)0.00080.42 (0.30-0.60)<0.0005
  • *Heterozygous genotypes were encoded as intermediate between C/C and T/T genotypes.