Table 2.

Association between mTOR pathway genetic polymorphisms and bladder cancer

GeneSNP*Alleles (major/minor)MAFBest fitting modelPH-W
CaseControlModelOR (95% CI)P
AKT3rs2994329G/A0.200.20Recessive2.11 (1.21-3.67)0.0080.262
RHEBrs717775A/C0.300.28Recessive1.60 (1.09-2.36)0.0160.361
RPS6KA5rs7155799G/A0.220.24Recessive0.57 (0.35-0.94)0.0290.612
IRS2rs9515120G/A0.070.05Dominant1.57 (1.12-2.19)0.0090.889
TSC2rs2073636G/A0.410.37Additive1.18 (1.01-1.38)0.0360.721
RAPTORrs11653499G/A0.310.26Additive1.22 (1.03-1.44)0.0190.662
RAPTORrs7212142G/A0.430.38Recessive1.36 (1.02-1.82)0.0370.463
RAPTORrs7211818A/G0.240.21Recessive2.16 (1.35-3.47)0.001§0.637
RAPTORrs7208536G/A0.280.24Recessive1.86 (1.20-2.89)0.0050.274
RAPTORrs4969444G/A0.200.17Recessive2.16 (1.22-3.82)0.0090.744
RAPTORrs2048753G/A0.270.24Additive1.22 (1.02-1.45)0.0300.513
RAPTORrs2672890G/A0.180.20Dominant0.79 (0.63-0.99)0.0440.542
RAPTORrs9897968G/A0.210.23Dominant0.79 (0.63-0.98)0.0360.823
RAPTORrs1877926G/A0.350.33Recessive1.43 (1.02-1.99)0.0360.886
RAPTORrs2271612A/G0.490.47Recessive1.39 (1.07-1.81)0.0130.033
RAPTORrs6420481A/G0.430.42Recessive1.36 (1.02-1.80)0.0340.135
RAPTORrs1062935A/G0.500.48Recessive1.29 (1.00-1.66)0.0470.219

Abbreviation: MAF, minor allele frequency.

  • *In raptor gene, we only listed one significant SNP per haplotype block with the smallest P value.

  • HWE test among controls.

  • Adjusting for age, sex, tobacco smoking, BMI, energy intake, and physical activity.

  • §q-value, <0.1.