Table 1.

Distribution of subjects' epidemiologic characteristics by SEZ6L SNP genotype

CharacteristicsSEZ6L genotypeP
GG freq (%)TG freq (%)TT freq (%)
Subject status
    Case104 (52)76 (38)20 (10)0.02
    Control111 (59)71 (38)6 (3)
Smoking duration (y)
    Never43 (61.4)25 (35.7)2 (2.9)0.81
    <2035 (54.7)24 (37.5)5 (7.8)
    20-3958 (54.7)39 (36.8)9 (8.5)
    40+79 (53.3)59 (39.9)10 (6.8)
History of pneumonia
    Yes34 (50.0)30 (44.1)4 (5.9)0.53*
    No181 (56.6)117 (36.6)22 (6.9)
Previous cancer diagnosis
    Yes14 (53.9)10 (38.5)2 (7.7)0.95*
    No201 (55.5)137 (37.9)24 (6.6)
Occupation asbestos exposure
    Yes73 (54.9)48 (36.1)12 (9.0)0.41
    No142 (55.7)99 (38.8)14 (5.5)
Family history of lung cancer
    No165 (55.4)109 (36.6)24 (8.0)0.16*
    Early onset13 (44.8)16 (55.2)0 (0.0)
    Late onset37 (60.6)22 (36.1)2 (3.3)
  • *P value for Fisher's exact test; no statistically significant interaction of SEZ6L with any of the risk factors in the LLP risk model.