Table 2.

Genotype frequencies for SEP15 tag SNPs in PCa cases and controls, and odds ratios and 95% CIs for PCa incidence, adjusting for matching factors (age at randomization, smoking, follow-up time)

SNPGenotype frequencyOdds ratio (95% CI)
Cases, n (%)Controls, n (%)All casesAggressive cases*
rs5859
    GG751 (62.9)738 (62.2)1.00 (reference)1.00 (reference)
    AG387 (32.4)394 (33.2)0.97 (0.81-1.15)1.03 (0.78-1.36)
    AA57 (4.8)54 (4.6)1.04 (0.70-1.53)0.92 (0.49-1.74)
    Ptrend0.881.00
rs479341
    CC779 (63.6)773 (63.6)1.00 (reference)1.00 (reference)
    CT382 (31.2)387 (31.9)0.98 (0.83-1.17)1.09 (0.83-1.42)
    TT64 (5.2)55 (4.5)1.16 (0.80-1.69)1.34 (0.78-2.30)
    Ptrend0.740.29
rs561104
    GG193 (16.3)190 (16.4)1.00 (reference)1.00 (reference)
    AG596 (50.3)552 (47.6)1.06 (0.84-1.34)0.89 (0.62-1.28)
    AA397 (33.5)419 (36.1)0.93 (0.73-1.19)0.94 (0.65-1.36)
    Ptrend0.370.86
rs527281
    CC1,086 (87.0)1,058 (86.9)1.00 (reference)1.00 (reference)
    CG149 (11.9)157 (12.9)0.93 (0.73-1.18)1.17 (0.83-1.67)
    GG13 (1.0)2 (0.2)6.28 (1.41-27.88)4.36 (0.60-31.42)
    Ptrend0.580.21
rs1407131
    AA912 (75.0)896 (75.6)1.00 (reference)1.00 (reference)
    AG279 (22.9)261 (22.0)1.05 (0.87-1.28)0.99 (0.73-1.35)
    GG26 (2.1)28 (2.4)0.91 (0.53-1.57)1.71 (0.86-3.40)
    Ptrend0.820.39
  • *Gleason score ≥8, clinical stage T3, T4, N1, or M1, or lethal PCa.

  • Under a recessive model, rs527281 odds ratio is 6.34 (95% CI, 1.43-28.13); P = 0.02.