Table 3.

ORs of prostate cancer by serum protein carbonyl levels

Protein carbonyls (nmol/mL)*CombinedFinasteride armPlacebo arm
Cases, n = 1,801Controls, n = 1,797OR (95% CI)Cases, n = 760Controls, n = 760OR (95% CI)Cases, n = 1,041Controls, n = 1,037OR (95% CI)
Quartile 1 (<17.35)4684491.001862031.002822461.00
Quartile 2 (17.5-19.5)4194510.93 (0.77-1.12)1801761.16 (0.86-1.57)2392750.79 (0.61-1.01)
Quartile 3 (19.6-22.1)4754461.09 (0.91-1.32)2081971.26 (0.94-1.68)2672490.97 (0.76-1.25)
Quartile 4 (>22.1)4394511.03 (0.85-1.24)1861841.27 (0.94-1.71)2532670.88 (0.69-1.12)
P-trend0.420.090.66

NOTE: All ORs were adjusted for age, race (white vs nonwhite), education (<HS, HS, ≥HS), smoking status (current, past, never), and physical activity (moderate or active vs sedentary or light). P-trend values were calculated by assigning values of 1/2/3/4 to OP quartiles and then treating as continuous.

  • *Quartile values were calculated based on controls only.