Table 1.

Effects of dietary Frondanol A5 treatment on p21, and PCNA expression in colonic ACFs of azoxymethane-treated F344 rats

Experimental groupp21 expression (%)PCNA expression (%)
NuclearCytoplasmic
Control (azoxymethane + solvent) diet20.1 ± 3.2*19.2 ± 2.466.3 ± 4.6
Treated (azoxymethane + 450 ppm Frondanol A5) diet59.1 ± 4.744.6 ± 3.528.6 ± 2.8

NOTE: PCNA and p21 expression was analyzed by immunohistochemistry using antibodies against PCNA and p21.

  • *Values are mean ± SEM (n = 8-10).

  • Values are significantly different from control group, by two-tailed Student's t test with Welch's correction.