Table 4.

Association between flavonol intake during the trial and colorectal adenoma recurrence among intervention group participants of the PPT (n = 872)

Flavonol quartiles* (mg/d)Adenoma recurrence (T4)
NoAdvancedHigh-riskAny
n (%)n (%)OR (95% CI)n (%)OR (95% CI)n (%)OR (95% CI)
<21.2128 (58.7)25 (11.5)1.0040 (18.3)1.0090 (41.3)1.00
21.2-29.7134 (61.5)11 (5.0)0.35 (0.16-0.76)22 (10.1)0.49 (0.27-0.90)84 (38.5)0.89 (0.60-1.33)
29.8-40.0124 (56.9)8 (3.7)0.32 (0.13-0.77)19 (8.7)0.54 (0.28-1.01)94 (43.1)1.16 (0.78-1.72)
>40.0138 (63.3)5 (2.3)0.17 (0.06-0.50)19 (8.7)0.51 (0.26-0.98)80 (36.7)0.96 (0.63-1.46)
P-trend§0.00020.020.87
  • *Flavonol intake in quartiles (Q1-Q4) by the mean consumption during the first 3 trial years.

  • Multivariate OR and 95% CI models were adjusted for age tertiles (<58, 58-66, >66 y), sex, average BMI (<25, 25.0-29.9, ≥30 kg/m2), and average energy intake (continuous) during the first 3 trial years.

  • Reference category.

  • §The ln-transformed median intakes (in mg/d) of each quartile were used as a continuous score variable to determine the P value for trend.