Table 2.

Toxic effects of protocol treatment over time period

Treatment groupTime periodNo. patients experiencing each grade of toxicity
1234
PCB + PCB (n = 50)All17710
PCB + CCX
    Dose 0 (n = 21)1st 3 mo6000
2nd 3 mo4100
    Dose +1 (n = 30)1st 3 mo10210
2nd 3 mo1320
CCX + PCB
    Dose 0 (n = 22)1st 3 mo2000
2nd 3 mo7100
    Dose +1 (n = 30)1st 3 mo5600
2nd 3 mo2400
CCX + CCX
    Dose 0 (n = 19)All4001
    Dose +1 (n = 32)All5410

Abbreviations: PCB, placebo; CCX, celecoxib; Dose 0, low-dose; Dose +1, high-dose.