Table 4.

Modulation of MI from baseline to 3 mo by treatment arm at each dose level, by smoking status

Smoking statusTreatmentVariablenMeanSDMinimumMedianMaximum
FormerCCX, dose 0MI086.258.630.000.0016.67
MI386.2512.400.000.0033.33
MI3080.0012.60−16.670.0016.67
CCX, dose +1MI074.768.130.000.0016.67
MI370.000.000.000.000.00
MI307−4.768.13−16.670.000.00
PlaceboMI0135.1310.510.000.0033.33
MI3131.284.620.000.0016.67
MI3013−3.8512.08−33.330.0016.67
CurrentCCX, dose 0MI02515.0021.970.000.0066.67
MI32516.1318.950.0016.6766.67
MI30251.1314.87−33.330.0033.33
CCX, dose +1MI02912.8714.930.0016.6750.00
MI32915.9217.880.0016.6766.67
MI30293.0518.44−33.330.0033.33
PlaceboMI04415.4523.180.000.0083.33
MI34416.0622.450.008.33100.00
MI30440.6122.43−50.000.0066.67

NOTE: One patient did not have a 3-mo MI reading from the biopsy.

Abbreviations: CCX, dose 0, low-dose celecoxib; CCX, dose +1, high-dose celecoxib; MI0, MI baseline; MI3, MI at 3 mo; MI30, MI difference (MI3 − MI0).