IL-6 (pg/mL) | Flavonol intake quartiles (mg/d)^{*} | P^{†} | |||
---|---|---|---|---|---|

Q1: <21.2 | Q2: 21.2-29.7 | Q3: 29.8-40.0 | Q4: >40.0 | ||

Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||

Sample size | 218 | 218 | 218 | 218 | |

Baseline (T0) | 2.02 (1.41-2.99) | 1.90 (1.38-2.97) | 1.79 (1.32-2.75) | 1.95 (1.31-2.69) | 0.30 |

Year 1 (T1) | 2.05 (1.41-3.23) | 2.00 (1.37-3.00) | 1.77 (1.26-2.46) | 1.83 (1.26-2.72) | 0.008 |

Year 3 (T3) | 2.30 (1.62-3.46) | 2.07 (1.58-3.25) | 1.99 (1.41-2.76) | 1.84 (1.35-2.64) | 0.0002 |

Trial (T1,3^{‡}) | 2.20 (1.61-3.19) | 2.07 (1.54-2.98) | 1.84 (1.37-2.51) | 1.80 (1.39-2.60) | 0.0002 |

Change (T1,3-T0^{‡}) | 0.17 (−0.30-0.60) | 0.19 (−0.54-0.67) | −0.01 (−0.40-0.44) | 0.01 (−0.51-0.48) | 0.07 |

↵*Participants were grouped in quartiles (Q1-Q4) by mean flavonol intake during the first 3 trial years.

↵

^{†}*P*values for differences in medians among the flavonol intake quartiles were calculated based on the Kruskal-Wallis test. The*P*value for trend using a multiple regression model adjusting for age tertiles (<58, 58-66, >66 y), sex, average BMI (<25, 25.0-29.9, ≥30 kg/m^{2}), current smoking status, and average energy intake (continuous) during the first 3 trial years was 0.01 for Trial (T1,3) and 0.10 for Change (T1,3-T0).↵

^{‡}Trial (T1,3) = geometric mean of year 1 and year 3 values. Change (T1,3-T0) = T1,3 minus baseline values.