Table 3.

The median time (y) to oral cancer development and OCF rates at years 5 and 10 in the subgroup of 49 patients with high EGFR expression and evaluation of EGFR gene copy number

VariableLevelNEventMedian (95% CI)OCF rate at 5 y (95% CI)OCF rate at 10 y (95% CI)P*
All patients49246.65 (3.52-NA)0.62 (0.5-0.78)0.46 (0.32-0.65)
SexFemale23116.67 (2.24-NA)0.54 (0.37-0.8)0.47 (0.28-0.76)0.737
Male26136.65 (5.22-NA)0.69 (0.53-0.89)0.46 (0.28-0.74)
RaceOther10NA0.489
White48246.65 (3.52-NA)0.61 (0.49-0.77)0.45 (0.32-0.64)
Histologic statusHyperplasia331410.7 (5.22-NA)0.68 (0.54-0.87)0.53 (0.36-0.77)0.454
Mild dysplasia1065.09 (2.05-NA)0.5 (0.27-0.93)
Moderate/severe dysplasia644.45 (1.85-NA)0.5 (0.22-1)
Treatment arm13cRA24136.21 (2.88-NA)0.53 (0.36-0.78)0.41 (0.24-0.69)0.452
BC + RP18710.7 (5.3-NA)0.72 (0.54-0.96)0.62 (0.4-0.94)
RP745.22 (2.05-NA)0.71 (0.45-1)
Smoking historyCurrent165NA (6.67-NA)0.75 (0.57-1)0.471
Former25156.21 (2.88-NA)0.56 (0.4-0.79)0.39 (0.23-0.67)
Never845.3 (3.36-NA)0.6 (0.33-1)0.45 (0.2-1)
Alcohol historyCurrent291210.7 (6.65-NA)0.72 (0.58-0.91)0.56 (0.38-0.81)0.272
Former853.32 (2.27-NA)0.47 (0.21-1)
Never1273.36 (1.85-NA)0.44 (0.21-0.92)0.29 (0.1-0.87)
EGFR gene copy number§FISH−298NA0.79 (0.65-0.95)0.67 (0.5-0.9)0.0007
FISH+20162.88 (2.05-NA)0.4 (0.23-0.68)0.16 (0.05-0.53)
  • *P values are from the log-rank test (univariate analysis).

  • §FISH−: disomy; FISH+: low trisomy, high trisomy, low polysomy, or gene amplification.