CYP isozyme | Index values^{*} | Post- to pre-intervention ratio | P^{†} | |
---|---|---|---|---|

Pre | Post | |||

1A2 | 3.95 ± 0.38^{‡} (n = 36) | 3.33 ± 0.29 (n = 36) | 0.84 (0.78-0.91)^{§} | 0.0005 |

3A4 | 73.2 ± 12.8 (n = 39) | 97.1 ± 16.7 (n = 39) | 1.33 (1.11-1.59) | 0.01 |

2D6 | 0.07 ± 0.02 (n = 38) | 0.12 ± 0.04 (n = 35) | 1.70 (1.23-2.19) | 0.01 |

2C9 | 1.02 ± 0.11 (n = 39) | 2.78 ± 0.36 (n = 39) | 2.71 (2.22-3.31) | <0.0001 |

↵*Caffeine/paraxanthine ratio in 4-h postdose plasma as CYP1A2 index; buspirone AUC [(ng/mL)·min] as CYP3A4 index; dextromethorphan/dextrorphan molar ratio in 0-8 h postdose urine as CYP2D6 index; losartan/E3174 ratio in 0-8 h postdose urine as CYP2C9 index.

↵

^{†}Paired*t*test on log-transformed indices.↵

^{‡}Geometric mean ± SE; SE was derived from a delta method.↵

^{§}Geometric mean ratio (90% CI).