Table 1.

CYP phenotypic indices before and after 4 wk of daily resveratrol administration (1 g QD)

CYP isozymeIndex values*Post- to pre-intervention ratioP
PrePost
1A23.95 ± 0.38 (n = 36)3.33 ± 0.29 (n = 36)0.84 (0.78-0.91)§0.0005
3A473.2 ± 12.8 (n = 39)97.1 ± 16.7 (n = 39)1.33 (1.11-1.59)0.01
2D60.07 ± 0.02 (n = 38)0.12 ± 0.04 (n = 35)1.70 (1.23-2.19)0.01
2C91.02 ± 0.11 (n = 39)2.78 ± 0.36 (n = 39)2.71 (2.22-3.31)<0.0001
  • *Caffeine/paraxanthine ratio in 4-h postdose plasma as CYP1A2 index; buspirone AUC [(ng/mL)·min] as CYP3A4 index; dextromethorphan/dextrorphan molar ratio in 0-8 h postdose urine as CYP2D6 index; losartan/E3174 ratio in 0-8 h postdose urine as CYP2C9 index.

  • Paired t test on log-transformed indices.

  • Geometric mean ± SE; SE was derived from a delta method.

  • §Geometric mean ratio (90% CI).