Table 3.

Univariate analysis of association between predictors and histology, excluding patients with known cancer at presentation (n = 161)

VariableBenign (n = 113)Dysplasia/cancer (n = 48)OR* (95% CI)P*
Age (y)
    Mean (±SD)52 (±13)56 (±15)1.2 (0.9-1.6)0.110
    Median (range)52 (18-78)57 (24-86)
Gender, n (%)
    Female36 (31.9)15 (31.3)Reference
    Male77 (68.1)33 (68.7)1.0 (0.5-2.1)0.940
Race, n (%)
    African American28 (24.8)10 (20.8)Reference
    White77 (68.1)36 (75.0)1.3 (0.6-3.0)0.639
    Other8 (7.1)2 (4.2)0.7 (0.1-3.9)
Tobacco, n (%)
    Never user37 (32.7)14 (29.2)Reference
    Former user20 (17.7)10 (20.8)1.3 (0.5-3.5)0.855
    Current user56 (49.6)24 (50.0)1.1 (0.5-2.5)
Ethanol, n (%)
    Never used33 (29.2)12 (25.0)Reference
    Used80 (70.8)36 (75.0)1.2 (0.6-2.7)0.587
Risk classification, n (%)
    Low risk75 (66.4)21 (43.8)Reference
    High risk38 (33.6)27 (56.2)2.5 (1.3-5.1)0.008
EDNRB, n (%)
    Unmethylated88 (77.9)30 (62.5)Reference
    Methylated25 (22.1)18 (37.5)2.1 (1.0-4.4)0.046
KIF1A, n (%)
    Unmethylated84 (74.3)35 (72.9)Reference
    Methylated28 (24.8)13 (27.1)1.1 (0.5-2.4)0.782
    Missing1 (0.9)0 (0)
  • *Univariate logistic regression model.

  • Unit of 10 y.

  • Excluded from the analysis of association.