Table 2.

Relative risk for each unit of the diversity measure for progression to adenocarcinoma, evaluated for mean pairwise genetic divergence and the entropy-based measures with varying q values (Eq. A) with different alterations used to define a clone

LOH, microsatellite shifts and mutationsLOH onlySelective lociNeutral loci
RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)
Divergence (per 10%)1.46 (1.20-1.77)1.87 (1.38-2.54)1.41 (1.23-1.61)1.58 (1.22-2.05)
q = 01.68 (1.46-1.94)1.71 (1.48-1.98)2.17 (1.67-2.82)1.86 (1.57-2.2)
q = 0.21.77 (1.52-2.06)1.77 (1.52-2.07)2.29 (1.7-3.09)1.91 (1.6-2.29)
q = 0.41.84 (1.56-2.16)1.81 (1.54-2.13)2.35 (1.7-3.26)1.95 (1.61-2.36)
q = 0.61.88 (1.59-2.23)1.84 (1.56-2.18)2.36 (1.67-3.34)1.98 (1.62-2.41)
q = 0.81.91 (1.61-2.28)1.87 (1.57-2.22)2.34 (1.63-3.37)2 (1.62-2.46)
q = 11.93 (1.62-2.31)1.88 (1.58-2.25)2.32 (1.59-3.37)2.02 (1.62-2.51)
q = 1.21.95 (1.62-2.34)1.9 (1.58-2.28)2.28 (1.55-3.36)2.03 (1.62-2.56)
q = 1.41.96 (1.63-2.37)1.91 (1.59-2.3)2.25 (1.52-3.34)2.05 (1.62-2.6)
q = 1.61.97 (1.63-2.38)1.92 (1.59-2.32)2.22 (1.49-3.33)2.06 (1.61-2.63)
q = 1.81.98 (1.63-2.4)1.93 (1.59-2.34)2.2 (1.46-3.31)2.08 (1.61-2.67)
q = 21.98 (1.63-2.41)1.94 (1.6-2.36)2.18 (1.44-3.3)2.09 (1.61-2.7)
q = 2.21.99 (1.63-2.43)1.95 (1.6-2.38)2.16 (1.41-3.29)2.1 (1.61-2.74)
q = 2.41.99 (1.63-2.44)1.96 (1.6-2.4)2.14 (1.4-3.28)2.11 (1.61-2.77)
q = 2.62 (1.63-2.45)1.97 (1.6-2.41)2.13 (1.38-3.28)2.12 (1.61-2.79)
q = 2.82.01 (1.63-2.46)1.97 (1.61-2.43)2.11 (1.37-3.27)2.13 (1.61-2.82)
q = 32.01 (1.63-2.48)1.98 (1.61-2.44)2.1 (1.35-3.27)2.14 (1.61-2.84)

NOTE: P < 0.001 for all diversity measures. q = 0 measures the number of clones; the RR is per clone. q = 1 is the Shannon index and q = 2 is the Simpson index.