Epidemiological studies of metformin and cancer risk
| Source (Country) | Design & population | Site of cancer* | Mean age (yrs) | Period | Ca incidence/Ca mortality | No of cases | No of controls | Mean f-up (yrs) |
|---|---|---|---|---|---|---|---|---|
| Yang et al., 2004 (UK) (40) | Nested case-control study on type II diabetes patients | Colon | 75 | 1987-2002 | Yes/No | 125 | 1195 | 3.9 |
| Bowker et al., 2006 (Canada) (41) | Population-based, retrospective cohort study on type II diabetes patients | Any site | 63 | 1991-1996 | No/Yes | 407 | 10309† | 5.4 |
| Monami et al., 2008 (Italy) (43) | Hospital-based, case-control study on type II diabetes patients | Any site | 69 | 1998-2005 | Yes/No | 195 | 195 | 6.5 |
| Libby et al., 2009 (Scotland, UK) (36) | Population-based, historical cohort study on type II diabetes patients | Any site | 66 | 1994-2003 | Yes/Yes | 771 | 8170† | 7 |
| Currie et al., 2009 (UK) (44) | General practices, retrospective cohort study on type II diabetes patients | Any site | 64 | 2000-2005 | Yes/No | 373 | 7897† | 2.4 |
| Donadon et al., 2009 (Italy) (34) | Hospital Based Case-Control study | HCC | na | 1994-2006 | Yes/No | 465 | 490 | na |
| Landman et al., 2009 (Netherlands) (42) | General practice based cohort study on type II diabetes patients | Any site | 68 | 1998-2009 | No/Yes | 122 | 1353† | 9.6 |
| Wright et al., 2009 (USA, WA) (39) | Population-based, case-control study | Prostate | 60 | 2002-2005 | Yes/No | 1001 | 942 | 5 |
| Li et al., 2009 (USA, TX) (38) | Hospital-based, case-control study | Pancreas | 61 | 2004-2008 | Yes/No | 973 | 863 | na |
| Hassan et al., 2010 (USA, TX) (45) | Hospital-based, case-control study | HCC | 62 | 2000-2008 | Yes/No | 122 | 86 | na |
| Bodmer et al., 2010 (UK) (46) | Nested case-control study on type II diabetes patients | Breast | 68 | 1994-2005 | Yes/No | 17 | 120 | na |