Table 1.

Epidemiological studies of metformin and cancer risk

Source (Country)Design & populationSite of cancer*Mean age (yrs)PeriodCa incidence/Ca mortalityNo of casesNo of controlsMean f-up (yrs)
Yang et al., 2004 (UK) (40)Nested case-control study on type II diabetes patientsColon751987-2002Yes/No12511953.9
Bowker et al., 2006 (Canada) (41)Population-based, retrospective cohort study on type II diabetes patientsAny site631991-1996No/Yes407103095.4
Monami et al., 2008 (Italy) (43)Hospital-based, case-control study on type II diabetes patientsAny site691998-2005Yes/No1951956.5
Libby et al., 2009 (Scotland, UK) (36)Population-based, historical cohort study on type II diabetes patientsAny site661994-2003Yes/Yes77181707
Currie et al., 2009 (UK) (44)General practices, retrospective cohort study on type II diabetes patientsAny site642000-2005Yes/No37378972.4
Donadon et al., 2009 (Italy) (34)Hospital Based Case-Control studyHCCna1994-2006Yes/No465490na
Landman et al., 2009 (Netherlands) (42)General practice based cohort study on type II diabetes patientsAny site681998-2009No/Yes12213539.6
Wright et al., 2009 (USA, WA) (39)Population-based, case-control studyProstate602002-2005Yes/No10019425
Li et al., 2009 (USA, TX) (38)Hospital-based, case-control studyPancreas612004-2008Yes/No973863na
Hassan et al., 2010 (USA, TX) (45)Hospital-based, case-control studyHCC622000-2008Yes/No12286na
Bodmer et al., 2010 (UK) (46)Nested case-control study on type II diabetes patientsBreast681994-2005Yes/No17120na
  • *Site cancer included in the analysis; HCC: hepatocellular carcinoma.

  • Persons at risk; na: data could not be retrievable from the published paper.