Table 1.

Characteristics of subjects in the methylation analysis

CharacteristicIndividuals included in the methylation analysis (n = 388)Individuals included in the entire study (n = 1,121)
Age, mean (SD), y57.8 (9.1)57.5 (9.6)
Male, n (%)246 (63.4)712 (63.5)
Smoker, n (%)58 (15.0)164 (14.5)
Alcohol drinker, n (%)123 (33.0)340 (31.5)
Treatment
 Placebo123 (31.7)372 (33.2)
 Aspirin 80 mg/d137 (35.3)377 (33.6)
 Aspirin 325 mg/d128 (33.0)372 (33.2)
Treatment
 Placebo190 (49.0)505 (49.5)
 Folate 1 mg/d198 (51.0)516 (50.5)
Race or ethnic group, n (%)
 White325 (83.8)958 (85.5)
 African American22 (5.7)68 (6.1)
 Hispanic22 (5.7)61 (5.4)
 Other19 (4.9)34 (3.0)
BMI, mean (SD)27.3 (4.6)27.4 (4.5)
Baseline plasma folate, mean (SD), nmol/L20.9 (15.4)23.3 (15.6)
Year 3 plasma folate, mean (SD), nmol/L53.4 (36.5)50.6 (34.7)
Baseline RBC folate, mean (SD), ng/mL396.4 (141.5)407.9 (152.9)
Year 3 RBC folate, mean (SD), ng/mL809.3 (345.5)836.8 (303.5)
Dietary intake
 Total calories, mean (SD), kcal/d1,601.4 (624.8)1,634 (667.0)
 Carbohydrates, mean (SD), g/d180.3 (72.4)185.9 (77.4)
 Fat (total), mean (SD), g/d63.7 (32.6)65.1 (34.3)
 Fiber, mean (SD), g/d12.8 (5.9)13.3 (6.0)
 Folate, mean (SD), μg/d305.0 (7.7)319.9 (156.6)
 Protein, mean (SD), g/d64.2 (25.2)65.4 (27.1)