Table 2.

Anal tumors selectively arise in E6/E7 mice treated with 0.12 μmol DMBA

Histologic classification of disease
GenotypenNormalHyperplasiaPapillomaAtypia (%)aCancer (%)b
NTG3232000 (0)0 (0)
E6/E7316549 (29)7 (23)

Abbreviation: NTG, nontransgenic.

  • aP < 0.01 comparing presence of atypia in NTG mice versus E6/7 mice.

  • bP < 0.01 comparing presence of cancer in NTG mice versus E6/7 mice.