Table 6.

Association between tertiles of percentage ERα and SFRP1 methylation and risk of different types of large bowel polyps

TertilesAdenomaAdvanced adenomaHyperplastic polypHyperplastic polyp, right colon
NRRa (95% CI)NRRa (95% CI)NRRa (95% CI)NRRa (95% CI)
ERα
 Tertile 1 (n = 332)1301.0261.0561.0111.0
 Tertile 2 (n = 337)1481.06 (0.88–1.27)281.08 (0.65–1.88)751.35 (0.99–1.86)191.42 (0.67–3.04)
 Tertile 3 (n = 327)1511.00 (0.83–1.21)200.85 (0.47–1.55)671.33 (0.94–1.84)141.72 (0.78–3.77)
P for trend0.990.600.090.18
SFRP1
 Tertile 1 (n = 332)1311.0251.0611.0131.0
 Tertile 2 (n = 330)1471.01 (0.84–1.22)291.17 (0.67–2.03)771.25 (0.92–1.71)201.39 (0.69–2.83)
 Tertile 3 (n = 330)1480.93 (0.76–1.13)180.72 (0.37–1.38)580.98 (0.69–1.38)110.98 (0.43–2.27)
P for trend0.440.320.890.97
  • aR2 adjusted for age, sex, treatment assignment, smoking status, alcohol intake, and time since randomization.