DMBA dose correlates with increase in tumor incidence and carcinogenesis in E6/E7 anal tissue
| Phenotype | Histologic classification | ||||
|---|---|---|---|---|---|
| Genotype | Dose (μmol) | n | Overt tumor | Atypia (%) | Cancer (%) |
| Nontransgenic | 0.12 | 32 | 0 0 | 0 (0) | 0 (0) |
| E6/E7 | 0.12 | 31 | 14 | 9 (29) | 7 (23) |
| E6/E7 | 0.04 | 30 | 0 5 | 6 (20) | 0 (0) |
| E6/E7 | 0.012 | 31 | 0 1 | 0 (0) | 0 (0) |
| E6/E7 | DMSO only | 10 | 0 0 | 0 (0) | 0 (0) |