Table 2.

Association between % ERα methylation and selected demographic, lifestyle, and dietary variables in the rectum and right colon

Counts NT/NL/NROverall Meana (SE)PbRectum Meana (SE)PbRight colon Meana (SE)PbPc
Age, y
 Q1 (30–52)107/107/1069.0 (0.2)0.00110.0 (0.3)0.0018.1 (0.3)0.0010.18
 Q2 (53–58)96/96/9610.3 (0.3)11.4 (0.4)9.3 (0.3)
 Q3 (59–64)93/92/9211.6 (0.4)13.0 (0.5)10.2 (0.5)
 Q4 (65–78)92/92/9112.9 (0.4)14.5 (0.6)11.2 (0.5)
Sex
 Male246/245/24410.9 (0.2)0.9512.3 (0.3)0.339.5 (0.2)0.270.09
 Female142/141/14210.9 (0.3)11.9 (0.3)9.9 (0.4)
Race
 White325/324/32411.1 (0.2)0.000812.4 (0.3)0.0049.9 (0.2)0.0030.04
 African American22/22/219.0 (0.5)9.5 (0.7)8.5 (0.5)
 Hispanic22/22/229.7 (0.7)10.8 (0.9)8.5 (0.6)
 Other19/19/1910.0 (0.6)12.1 (0.9)8.0 (0.5)
Smoking
 Never164/164/16310.7 (0.2)0.5911.9 (0.3)0.349.5 (0.3)0.870.29
 Former163/163/16311.2 (0.3)12.6 (0.4)9.8 (0.3)
 Current60/59/5810.4 (0.4)11.3 (0.5)9.6 (0.4)
Alcohol
 Never123/123/12211.4 (0.4)0.0712.9 (0.5)0.109.9 (0.4)0.210.42
 1 per day85/84/8510.7 (0.2)11.8 (0.3)9.6 (0.3)
 2+ per day165/165/16310.5 (0.3)11.8 (0.4)9.3 (0.3)
Treatment
 Placebo190/189/18911.0 (0.2)0.3512.5 (0.4)0.169.7 (0.2)0.960.23
 Folate198/198/19610.7 (0.2)11.8 (0.3)9.6 (0.3)
Treatment
 Placebo128/127/12710.9 (0.3)0.5811.8 (0.3)0.4310.0 (0.4)0.100.13
 Aspirin 81137/137/13611.0 (0.3)12.4 (0.5)9.7 (0.3)
 Aspirin 325123/123/12210.7 (0.3)12.2 (0.4)9.2 (0.3)
Multivitamin used
 No256/255/25311.2 (0.3)0.0612.6 (0.3)0.029.7 (0.3)0.600.13
 Yes130/130/13010.6 (0.2)11.6 (0.3)9.5 (0.3)
Dietary folate, μg/d
 Q1 (78.08–205.86)94/94/9310.6 (0.3)0.4011.7 (0.4)0.269.5 (0.4)0.850.60
 Q2 (206.87–277.3)94/94/9411.1 (0.4)12.3 (0.5)9.8 (0.4)
 Q3 (277.31–373.65)94/94/9310.6 (0.4)11.7 (0.4)9.6 (0.5)
 Q4 (376.17–1,285.59)93/91/9211.2 (0.4)12.8 (0.6)9.7 (0.3)
Dietary protein, g/d
 Q1 (17.00–44.91)94/94/9310.7 (0.3)0.2111.9 (0.4)0.119.4 (0.3)0.740.34
 Q2 (45.15–60.32)94/93/9411.7 (0.4)13.1 (0.6)10.2 (0.3)
 Q3 (60.70–78.71)94/94/9310.9 (0.3)12.4 (0.4)9.5 (0.4)
 Q4 (78.82–144.62)93/92/9210.3 (0.3)11.2 (0.4)9.5 (0.5)

Abbreviations: NT, total individuals; NL, total individuals with samples in the rectum; NR, total individuals with samples on the right side.

  • aMeans are adjusted for age, sex, randomized folate treatment assignment, smoking status, alcohol intake, and adenoma occurrence during the 3-year randomized period.

  • bP value for trend.

  • cMultivitamins used during the trial did not contain folic acid.

  • dP value for interaction between colorectal location and variables in the table.