Table 3

Inflammatory signaling and immune response genes that were down-regulated following estrogen administration

GeneGenbank no.Description
Antigen presentation pathway
CD74NM_004355CD74, MHC, class II chain
HLA-DMANM_006120MHC, class II, DM α
HLA-DMBNM_002118MHC, class II, DM β
HLA-DPA1NM_033554MHC, class II, DP α1
HLA-DPB1NM_002121MHC, class II, DP β1
HLA-DQA1NM_002122MHC, class II, DQ α1
HLA-DRANM_019111MHC, class II, DR α
HLA-DRB1NM_002124MHC, class II, DR β1
HLA-DRB3NM_022555MHC, class II, DR β3
HLA-DRB4NM_021983MHC, class II, DR β4
HLA-DRB5NM_002125MHC, class II, DR β5
HLA-ENM_005516MHC, class I, E
IL-4 signaling
HLA-DMANM_006120MHC, class II, DM α
HLA-DMBNM_002118MHC, class II, DM β
HLA-DQA1NM_002122MHC, class II, DQ α1
HLA-DQB1NM_002123MHC, class II, DQ β1
HLA-DRANM_019111MHC, class II, DR α
HLA-DRB1NM_002124MHC, class II, DR β1
HLA-DRB5NM_002125MHC, class II, DR β5
PIK3CGNM_002649Phosphoinositide-3-kinase, catalytic, γ polypeptide
Chemokine signaling
CCL4NM_002984Chemokine (C-C motif) ligand 4
CCL5NM_002985Chemokine (C-C motif) ligand 5
CCL24NM_002991Chemokine (C-C motif) ligand 24
CXCR4NM_003467Chemokine (C-X-C motif) receptor 4
FOSNM_005252v-fos FBJ murine osteosarcoma viral oncogene homologue
PIK3CGNM_002649Phosphoinositide-3-kinase, catalytic, γ polypeptide
PLCG2NM_002661Phospholipase C, γ 2 (phosphatidylinositol specific)
Complement system
C2NM_000063Complement component 2
C1QANM_015991Complement component 1, q subcomponent, A chain
C1QBNM_000491Complement component 1, q subcomponent, B chain
C1QCNM_172369Complement component 1, q subcomponent, C chain

NOTE: Some genes belong to more than one pathway.