Table 1

Most highly deregulated transcripts in mammary epithelium from p53-null transgenic mice for each chemopreventive treatment assessed (fold change ≥7; P < 0.01)

TagGeneDescriptionEntrez geneFold change*
Bexarotene treatment
 GTTTGCTGTASerpinb6aSerine (or cysteine) peptidase inhibitor2071917.0
 AGTCTCGAGGSlc1a5Solute carrier family 12051412.0
 GGTTTGGGGGJupJunction plakoglobin1648011.0
 TGCGTGCTGGTimp2Tissue inhibitor of metalloproteinase 22185811.0
 TTGAAATTACBC061494CDNA sequence38183211.0
 GATTTCTTTGGpc3Glypican 31473410.0
 TAACCAAAAAItgb4Integrin β419289710.0
 CCCAGTCCCTLtbp4Latent transforming growth factor binding protein 41080758.0
 GACTCTATATCsn2Casein β12991−15.0
 CAATAAAACASar1bSAR1 gene homologue B (S. cerevisiae)66397−11.0
 GCAGCGATTCNme2Expressed in nonmetastatic cells 218103−10.0
 TGTTCTATGGLaptm5Lysosomal-associated protein transmembrane 516792−9.0
 GTGTTTTGCTAI451557Expressed sequence102084−9.0
 CTAGGTGGTGGlycam1Glycosylation dependent cell adhesion molecule 114663−8.8
 TAAAGTCAATMuc15Mucin15269328−8.0
 TCAGAGTGAGIgh-6Immunoglobulin heavy chain 616019−7.5
Gefitinib treatment
 TGGATCCTGAHbb-b1Hemoglobin β adult major chain1512925.0
 ACTACTGAGGStnoStrawberry notch homologue (Drosophila)21616118.0
 CAAGAGGTTGFxyd3FXYD domain-containing ion transport regulator 31717818.0
 CTTATCTGTTVil2Villin 22235015.0
 GAAATGATGAPfdn5Prefoldin 55661213.8
 CTTTGGGGACDscr1Down syndrome critical region homologue 1 (human)5472013.0
 ATTCTCTGGAAtp2a2ATPase, Ca2+ transporting1193813.0
 CTTCCCTGTTCtnna1Catenin α1 (cadherin associated protein)1238513.0
 TCCTAAAAAAMyh9Myosin, heavy polypeptide 9, nonmuscle17886−33.0
 ACACCAAAAAAebp1AE binding protein 111568−22.0
 ATACAAATTAJak2Janus kinase 216452−14.0
 CACTGATTTAYwhabTyrosine 3-monooxygenase/tryptophan 5-monoox.54401−13.0
 GTGTGAAATARanbp2RAN binding protein 219386−13.0
 CTTCCCTAAT6720456B07RIKEN cDNA 6720456B07 gene101314−13.0
 ACACCCCTTCRhojRas homologue gene family, member J80837−12.0
 TAATGATATTNcoa7Nuclear receptor coactivator 7211329−12.0
Celecoxib treatment
 CCCAAGTGTAIgl-V1Immunoglobulin lambda chain, variable 11614215.0
 AAATTTGTTCAW555464Expressed sequence21788211.0
 TGAATGGCCTKlhdc2Kelch domain containing 26955411.0
 CAACTGTATTAco2Aconitase 2, mitochondrial1142910.0
 CCTGCTCTGTPrpf19PRP19/PSO4 pre-mRNA processing factor 19 homologue2800010.0
 GATGGTACATStc2Stanniocalcin 22085610.0
 TGAAAATCTAAbp1Amiloride binding protein 1765078.5
 AACAATCTGAPck2Phosphoenolpyruvate carbokinase 2745517.0
 TGTATAAATAMap2k1ip1Mitogen-activated protein kinase 1 interacting pro.156692−11.0
 AATACACTTGFam18bFamily with sequence similarity 18, member B67510−10.0
 TCGTTTTTTAAkt1Thymona viral proto-oncogene 111651−9.0
 GGGTTCAGCTRbck1RanBP-type and C3HC4-type zinc finger24105−9.0
 CAGGGAAACCPolr2ePolymerase (RNA) II polypeptide E66420−9.0
 TTGAAAATAAAnapc1Anaphase promoting complex subunit 117222−9.0
 CAGGCCATCCDkkI1Dickkopf-like 150722−8.0
 GGGATATAAADnaja1DnaJ (Hsp40) homologue, subfamily A, member 115502−7.0
  • *Up-regulated transcripts for each treatment are represented by positive fold changes and down-regulated transcripts are represented by negative fold changes.