Table 5

Regression models, including coefficients, for effect of topical application of free dl-α-tocopherol on number of AKs and expression of p53, PCNA, or polyamine levels

Overall effect of free dl-α-tocopherolEffect of baseline levelR2
95% CIP95% CIP
AK*2.0 (−1.3 to 5.3)0.2260.3 (−0.6 to −0.1)0.0070.17
p53−6.1 (−12.9 to 0.7)0.078−1.0 (−1.3 to −0.6)>0.0010.44
PCNA1.3 (−1.3 to 4.0)0.308−0.5 (−0.8 to −0.3)0.0010.27
Putrescine−60.4 (−79.6 to −41.2)<0.0001−1.04 (−1.3 to −0.8)<0.00010.65
Spermidine−60.5 (−86.2 to −34.8)<0.0001−1.29 (−1.6 to −1.0)<0.00010.70
Spermine−28.2 (−45.2 to −11.3)0.002−1.25 (−1.5 to −1.0)<0.00010.80
Total polyamines149.1 (−214.3 to −83.9)<0.0001−2.18 (−3.6 to −2.0)<0.00010.69
Spermidine to spermine ratio0.005 (−.10 to 0.11)0.111.04 (0.7 to 1.3)<0.00010.60