Table 2.

Effect of micronutrients on the incidence of liver metastasis

Histologic gradingControl (n = 12), % (n)E+S (n = 26), % (n)E+S+L age of animals at intervention (wk), % (n)
4 (n = 10)8 (n = 13)20 (n = 10)36 (n = 11)
No metastasis25 (3)34.6 (9)90 (9)*84.6 (11)70 (7)45.5 (5)
Metastatic undifferentiated75 (9)65.4 (17)10 (1)15.4 (2)30 (3)54.5 (6)

NOTE: Histologically, liver tissue was classified as normal or those that showed metastatic undifferentiated carcinomas. The incidence of liver metastasis was significantly lower if micronutrient intervention was commenced early on in the life of the animals [10% (P < 0.0001) and 15.4% (P < 0.0001) at 4 and 8 wk of age]. There was reduction in the frequency of liver metastasis in the animals supplemented with E+S, although this was not significant.

  • *Significantly different from control (P < 0.0001).

  • Significantly different from control (P < 0.0001).

  • Significantly different from control (P < 0.05).