Table 3.

Risk of histology progression

Risk of progression*Comparison (treated/observed)
ObservationTreatedOdds ratio (95% CI)P
All subjects
    n2748
    Maximum15 (55.6%)24 (50.0%)0.97 (0.36-2.66)0.95
    Average20 (74.1%)27 (56.2%)0.48 (0.17-1.37)0.17
    Dysplasia index19 (70.4%)23 (47.9%)0.39 (0.14-1.10)0.08
Current smokers
    n1221
    Maximum4 (33.3%)11 (52.4%)2.67 (0.55-12.98)0.22
    Average9 (75.0%)12 (57.1%)0.44 (0.09-2.16)0.31
    Dysplasia Index9 (75.0%)10 (47.6%)0.28 (0.05-1.45)0.13
Former smokers
    n1527
    Maximum11 (73.3%.)13 (48.1%)0.41 (0.10-1.71)0.22
    Average11 (73.3%,)15 (55.6%)0.52 (0.13-2.15)0.37
    Dysplasia index10 (66.7%)13 (48.1%,)0.48 (0.13-1.83)0.28
  • *Progression defined as worsening of a subject's histologic score or failure to obtain a follow-up bronchoscopy.

  • Adjusted for baseline histology (either maximum, average, or dysplasia index). All subject analysis is also adjusted for smoking status.