Table 6.

Change in Ki67

ObservationTreatedDifference* (treated − observed)
Difference95% CIP
All subjects
    n1732
    Maximum−5.14 (34.55)−8.09 (33.04)−1.48(−18.24 to 15.29)0.86
    Average5.63 (21.22)−1.68 (19.20)−4.69(−15.94 to 6.57)0.41
    Ki67 fraction0.04 (0.40)0.03 (0.38)−0.02(−0.23 to 0.20)0.88
Current smokers
    n914
    Maximum−10.00 (36.92)−13.77 (38.83)3.58(−22.47 to 29.62)0.78
    Average5.31 (27.29)−1.63 (22.54)−3.54(−23.64 to 16.56)0.72
    Ki67 Fraction−0.01 (0.49)0.07 (0.38)0.04(−0.32 to 0.40)0.81
Former smokers
    n818
    Maximum0.34 (33.27)−3.67 (28.12)−3.93(−26.28 to 18.42)0.72
    Average5.99 (13.31)−1.73 (16.84)−5.76(−18.87 to 7.35)
    Ki67 fraction0.09 (0.30)−0.01 (0.38)−0.08(−0.36 to 0.20)0.57
  • *Adjusted for baseline Ki67 level (either maximum, average, or fraction) “All subject” analysis is also adjusted for smoking status. Ki67 fraction is proportion of all samples within the individuals in which the Ki67 percentage exceeds 15%.