Table 1

Possible clinical targets for cancer prevention with AMPK-activating drugs

AMPK pathway targetClinical targetReference
ACC (↑)Breast(74)
AKT/mTOR (↑)Breast, colon, head and neck, lung, prostate, lung, skin (melanoma)(1)
FAS (↑)Breast, ovary, prostate(4345)
HMG-CoA (↑)Breast, colon, prostate, skin (melanoma)(84)
IGF-I/IGF receptor (↑)Breast, colon, prostate(84)
LKB1 (↓)Breast, lung(13, 14)
TP53 (↓)Lung, esophagus, head and neck(84)
BRCA1 (↓)Breast, ovary(74)
PTEN (↓)Endometrium(73)