Table 5

Selected cardiovascular and thrombotic events according to baseline risk factors

Placebo twice daily200 mg celecoxib twice daily400 mg celecoxib twice dailyP value for nteraction
No risk factors at baseline
 Patients with no baseline risk factors (%)*108 (15.9)102 (14.9)103 (15.4)
 Patients experiencing event (%)1 (0.9)4 (3.9)2 (1.9)
One risk factor at baseline
 Patients with one baseline risk factor (%)228 (33.7)241 (35.3)244 (36.5)
 Patients experiencing event (%)5 (2.2)9 (3.7)12 (4.9)
Two or more risk factors at baseline
 Patients with ≥2 baseline risk factors (%)340 (50.3)340 (49.8)322 (48.1)
 Patients experiencing event (%)20 (5.9)28 (8.2)36 (11.2)
Association between number of risk factors and events0.515
Association between events and individual baseline risk factors
 Smoking (%)20 (4.9)28 (6.5)32 (7.9)0.514
 Hyperlipidemia (%)15 (5.8)17 (6.6)29 (11.5)0.210
 Diabetes (%)5 (8.2)7 (10.4)10 (15.2)0.385
 Hypertension (%)16 (5.7)21 (7.3)24 (9.2)0.864
 Atherosclerotic heart disease (%)7 (8.2)14 (18.4)18 (21.4)0.004
 Cerebrovascular disease (%)2 (13.3)4 (16.7)3 (18.8)0.828
 Age >65 y (%)9 (2.0)18 (3.8)26 (5.5)0.779

NOTE: Risk factors: cigarette smoking, hypertension, hyperlipidemia, atherosclerotic heart disease, cerebrovascular disease, diabetes.

  • *Percent of those with the risk factor who experienced an event in the time interval from first dose of study medication to 30 d after last dose of study medication.