Table 2.

Association of GST polymorphisms and SPM risk

GenotypesTotal, n (%)SPM-free, n (%)SPM, n (%)P*Adjusted HR (95% CI)
GSTM10.221
    Wild-type601 (49.6)553 (50.2)48 (44.0)1.0
    Null610 (50.4)549 (49.8)61 (56.0)1.4 (0.9-2.0)
GSTT1
    Wild-type960 (79.3)875 (79.4)85 (78.0)0.7271.0
    Null251 (20.7)227 (20.6)24 (22.0)1.1 (0.7-1.8)
GSTM1 + GSTT10.494
    M1 wild and T1 wild470 (38.8)433 (39.3)37 (33.9)1.0
    Either M1 null or T1 null621 (51.3)562 (51.0)59 (54.2)1.3 (0.8-1.9)
    M1 null and T1 null120 (9.9)107 (9.70)13 (11.9)1.6 (0.9-3.1)
Trend testP = 0.116
GSTP1_1050.028
    Ile/Ile484 (40.1)451 (41.1)33 (30.3)1.0
    Ile/Val + Val/Val723 (59.9)647 (58.9)76 (69.7)1.7 (1.1-2.5)
GSTP1_1140.575
    Ala/Ala1,021 (84.4)927 (84.2)94 (86.2)1.0
    Ala/Val + Val/Val189 (15.6)174 (15.8)15 (13.8)0.8 (0.5-1.5)
No. GSTP1 risk genotypes0.086
    0462 (38.3)431 (39.2)31 (28.7)1.0
    1-2678 (56.2)609 (55.5)69 (63.9)1.6 (1.1-2.5)
    3-466 (5.50)58 (5.30)8 (7.40)2.0 (0.9-4.3)
Trend testP = 0.018
  • *P values were calculated from χ2 test.

  • Adjusted for age, sex, ethnicity, smoking, and alcohol.