Table 1.

Serum markers levels before and after Polyphenon E treatment

Serum biomarkern*BeforeAfterAfter−beforeP
Mean (SD)Mean (SD)Mean (SD)Percent change
HGF (pg/mL)251,009.2 (521.2)782.9 (373.3)−226.3 (289.4)−18.9<0.001
VEGF (pg/mL)25395.2 (287.2)345.5 (264.4)−49.7 (104.2)−9.90.032
PSA (ng/mL)2511.0 (6.2)9.3 (5.1)−1.12 (1.94)−10.40.012
IGF-I (ng/mL)24238.0 (107.0)210.0 (119.9)−28.0 (57.2)−11.00.024
IGFBP-3 (ng/mL)244,064 (917)3,773 (1,109)−291 (606)−7.90.009
IGF-I/IGFBP-3240.0595 (0.024)0.0522 (0.026)−0.0029 (0.0123)−3.40.028
  • *Assay problems on one or more samples reduced the sample size from 26.

  • Wilcoxon signed rank test comparing before and after values.

  • Mean of differences does not always equal difference of the means.