Table 2.

Liver function tests before and after Polyphenon E treatment

Serum biomarkernBeforeAfterAfter−before*P
Mean (SD)Mean (SD)Mean (SD)Percent change
Total protein (g/dL)267.48 (0.51)6.66 (0.96)−0.82 (0.98)−10.7<0.001
Albumin (g/dL)264.17 (0.29)3.68 (.078)−0.51 (0.81)−11.90.002
Bilirubin (mg/dL)260.64 (0.29)0.62 (0.27)−0.13 (0.26)5.90.74
Conjugated bilirubin (mL/dL)100.20 (0.11)0.21 (0.12)0.0 (0.01)8.91.00
Alanine aminotransferase (units/L)2627.0 (16.0)26.2 (14.3)−1.88 (7.60)−0.70.19
Aspartate aminotransferase (units/L)2628.8 (26.1)25.5 (20.5)−4.13 (8.75)−7.60.021
Alkaline phosphatase (units/L)2677.1 (20.2)67.5 (18.8)−10.25 (9.89)−13.0<0.001
γ-Glutamyl transpeptidase (units/L)1156.6 (26.6)58.8 (43.9)−4.18 (8.28)−6.20.17
Amylase (units/L)11105.5 (68.0)71.4 (45.5)−21.2 (30.4)−14.00.028
Lipase (units/L)1030.8 (16.5)24.2 (13.6)−8.5 (13.4)−16.80.097
  • *Mean of differences does not always equal differences of the means.

  • Wilcoxon signed rank test comparing paired before and after values.

  • These tests were added after the study had started; data were available for only 11 patients.