Table 3.

The cumulative effects of unfavorable genotypes on SPT/recurrence

No. unfavorable genotypes*SPT/recurrence, n (%)No SPT/recurrence, n (%)HR (95% CI)P
Reference group ≤418 (10.91)147 (89.09)1Reference
5-662 (37.58)103 (62.42)4.29 (2.52-7.29)7.59 × 10−8
734 (61.82)21 (38.18)9.16 (5.52-17.83)1.80 × 10−14
≥825 (96.15)1 (3.85)26.72 (14.00-50.99)<1.00 × 10−20
P for trend<1.00 × 10−20
  • *Unfavorable genotype was based on the 12 chromosomal SNPs and 1 mtSNP as described in text.

  • Adjusted for age, gender, smoking status, ethnicity, tumor site, tumor stage, and treatment.