Table 2.

Association of HNSCC with marijuana use

VariablesCase n = 434 (%)Controls n = 547 (%)OR*95% CIOR95% CI
Marijuana use status
    Never318 (73.27)396 (72.39)1.001.00
    Former36 (8.29)41 (7.50)0.910.551.500.650.361.16
    Current80 (18.43)110 (20.11)0.760.531.090.520.340.80
    Ptrend0.140.00
Duration of marijuana use in lifetime (y)
    None318 (73.44)396 (72.39)1.001.00
    >0 to <1042 (9.70)59 (10.79)0.750.481.170.630.381.05
    10 to <2033 (7.62)55 (10.05)0.620.381.000.380.220.67
    ≥2040 (9.24)37 (6.76)1.140.701.870.670.381.20
    Missing10
    Ptrend0.570.01
Average frequency of marijuana use per week (times)
    <0.5318 (73.44)396 (72.53)1.001.00
    0.5 to <1.543 (9.93)71 (13.00)0.650.421.000.520.320.85
    1.5 to <4.531 (7.16)39 (7.14)0.850.511.420.620.341.12
    ≥4.541 (9.47)40 (7.33)1.060.641.730.550.310.99
    Missing11
    Ptrend0.790.01
Total numbers of marijuana use in lifetime (times/wk* y)
    None318 (73.44)396 (72.53)1.001.00
    >0 to <526 (6.00)37 (6.78)0.760.441.300.630.341.17
    5 to <1518 (4.16)42 (7.69)0.460.250.830.360.180.69
    15 to <9032 (7.39)43 (7.88)0.780.471.300.530.300.94
    ≥9039 (9.01)28 (5.13)1.460.852.490.780.411.47
    Missing11
    Ptrend0.970.03
Total amount of marijuana use in lifetime (ounces/wk* y)
    None318 (76.81)396 (76.89)1.001.00
    >0 to <1/1618 (4.35)34 (6.60)0.570.311.050.530.261.06
    1/16 to <322 (5.31)29 (5.63)0.790.431.440.570.291.12
    3 to <7.524 (5.80)28 (5.44)0.890.501.610.650.331.26
    ≥7.532 (7.73)28 (5.44)1.180.682.050.690.361.33
    Missing2032
    Ptrend0.970.08
Average amount of marijuana use per week (ounces)
    <3/32334 (80.68)430 (83.5)1.001.00
    3/32 to <1/425 (6.04)32 (6.21)0.890.511.560.600.321.14
    1/4 to <3/424 (5.80)22 (4.27)1.240.672.300.720.361.47
    ≥3/431 (7.49)31 (6.02)1.110.651.910.760.411.41
    Missing2032
    Ptrend0.580.22
Years since last marijuana use
    None318 (73.27)396 (72.39)1.001.00
    <291 (20.97)117 (21.39)0.810.581.150.570.380.86
    2 to <1210 (2.3)9 (1.65)1.110.442.830.730.252.18
    12 to <226 (1.38)16 (2.93)0.380.141.000.270.090.82
    ≥229 (2.07)9 (1.65)1.070.422.760.680.241.94
    Ptrend0.240.01
Age at starting of marijuana use
    None318 (73.27)396 (72.39)1.001.00
    10 to <1565 (14.98)78 (14.26)0.900.611.320.620.390.96
    15 to <2040 (9.22)50 (9.14)0.780.481.270.530.300.95
    ≥2011 (2.53)23 (4.20)0.510.241.090.390.170.90
    Ptrend0.070.00
  • *OR adjusted for age and gender.

  • OR adjusted for age, gender, race, education, family history of cancer, HPV-16, smoking (pack-year), and average drinks of alcohol per week.

  • P < 0.05.