Table 4.

Joint effects of marijuana use and smoking or alcohol consumption with HNSCC

VariablesMarijuana use status
NeverEver
OR (95% CI)Cases/ControlsOR (95% CI)Cases/controls
Smoking (pack-y)*
    Never1.0066/1410.48 (0.22-1.06)12/41
    <201.40 (0.86-2.27)56/960.51 (0.27-0.96)27/56
    ≥202.85 (1.86-4.36)196/1592.20 (1.30-3.74)77/54
Alcohol drinks/per wk
    <81.00124/2420.56 (0.32-0.96)35/73
    ≥82.01 (1.41-2.86)186/1501.21 (0.76-1.92)81/78
Smoking and alcohol
    Never and <81.0042/1020.60 (0.23-1.58)7/26
    Never and ≥81.96 (0.96-4.00)21/350.71 (0.22-2.31)5/15
    <20 and <81.70 (0.93-3.09)33/620.57 (0.25-1.32)13/31
    <20 and ≥82.06 (1.02-4.15)22/340.90 (0.39-2.07)14/25
    ≥20 and <82.35 (1.34-4.14)49/781.79 (0.74-4.31)15/16
    ≥20 and ≥86.38 (3.76-10.83)143/814.75 (2.58-8.76)62/38
    Interaction0.006
  • *Model 1: adjusted for age, gender, race, education, family history of cancer, HPV-16, and average drinks of alcohol.

  • Model 1: adjusted for age, gender, race, education, family history of cancer, HPV-16, and pack-years of smoking.

  • Model 1: adjusted for age, gender, race, education, family history of cancer, and HPV-16.