Table 3.

Association of HNSCC with marijuana use by HPV 16 antibody status

VariablesHPV 16Case n = 434 (%)Controls n = 547 (%)Stratified OR*95% CIJoint effects OR95% CI
Marijuana use status
    NeverNegative230 (76.67)361 (73.82)1.001.00
    Former21 (7.00)35 (7.16)0.620.311.240.650.341.27
    Current49 (16.33)93 (19.02)0.470.290.770.510.320.81
    Ptrend0.00
    NeverPositive88 (65.67)35 (60.34)1.004.712.967.51
    Former15 (11.19)6 (10.34)0.740.222.462.971.048.54
    Current31 (23.13)17 (29.31)0.520.211.332.681.355.30
    Ptrend0.17
    Interaction0.96
Average frequency of marijuana use per week
    <0.5Negative230 (76.67)361 (73.98)1.001.00
    0.5 to <1.5 25 (8.33)59 (12.09)0.470.260.860.500.280.88
    1.5 to <4.519 (6.33)34 (6.97)0.570.281.140.590.301.15
    ≥4.526 (8.67)34 (6.97)0.520.271.030.590.311.13
    Missing01
    Ptrend0.02
    <0.5Positive88 (66.17)35 (60.34)1.004.722.977.52
    0.5 to <1.518 (13.53)12 (20.69)0.480.181.332.741.236.14
    1.5 to <4.512 (9.02)5 (8.62)0.840.223.163.431.1210.56
    ≥4.515 (11.28)6 (10.34)0.550.151.952.020.695.90
    Missing10
    Ptrend0.38
    Interaction0.92

NOTE: All ORs were adjusted for age, gender, education, race, smoking (pack-year), and average drinks of alcohol.

  • *OR stratified by HPV 16 antibody status.

  • OR joint effect with HPV 16 antibody status.