Table 3

IC50 for the inhibitory effect of 1α,25(OH)2D3 and Gemini vitamin D analogues on the growth of MCF10DCIS.com breast cancer cells

Vitamin D and analoguesIC50 (nmol/L)*
1α,25(OH)2D33.2
Gemini 3582 (3582)0.2
Gemini 3586 (3586)0.2
Gemini 0072 (0072)0.4
Gemini 0097 (0097)0.6
  • *MCF10DCIS.com cells were treated with vitamin D analogues (0.01, 0.1, 1, 10, and 100 nmol/L) in 5% horse serum/DMEM/F12 medium for 3 d. IC50 values were determined using TableCurve two-dimensional v5.1 software.