Table 1

Prevention of NMU-induced breast cancer by vitamin D analogues

Treatment*Dose (μg/kg body weight)No. animalsBody weight at autopsy (grams; mean ± SE)Tumor burden (grams; mean ± SE)
Control (Vehicle)12242.7 ± 6.59.0 ± 2.8
Ro-26-2198 (2198)0.036224.3 ± 16.08.4 ± 4.1
Gemini 3582 (3582)0.16248.3 ± 10.69.2 ± 2.3
Gemini 3586 (3586)0.36235.0 ± 2.65.0 ± 2.0
Gemini 0084 (0084)0.036247.6 ± 8.16.4 ± 3.0
Gemini 0088 (0088)0.16255.7 ± 9.98.9 ± 2.9
Gemini 0072 (0072)0.36250.8 ± 9.53.6 ± 1.7 (P = 0.06)
Gemini 0097 (0097)0.36262.7 ± 7.03.4 ± 1.7 (P = 0.05)
  • *All rats (ages 21d) received NMU (50 mg/kg body weight, i.p.) 1 wk before injecting vitamin D analogues i.p. daily, 5 d a week for 9 wk.

  • Tumor burden; average tumor weight per rat at autopsy.

  • P is the value for the comparison of tumor burden in rats treated with vitamin D analogues when compared with control rats treated with vehicle alone.