Table 1

Inhibitory effect of silibinin on AOM-induced aberrant crypt foci incidence and multiplicity in Fisher 344 male rat colon

GroupsTreatmentIncidence of ACF formation (%)No. ACF/colonCrypt multiplicity of ACF
1 crypt2 crypts3 crypts≥4 crypts
1Control0/7 (0)
2AOM7/7 (100)169 ± 1571 ± 1160 ± 724 ± 614 ± 7
30.033% Sb + AOM7/7 (100)103 ± 13*44 ± 5*30 ± 5*19 ± 710 ± 4
40.1% Sb + AOM7/7 (100)79 ± 11*24 ± 9*26 ± 7*17 ± 912 ± 4
5 0.33% Sb + AOM6/6 (100)68 ± 12*28 ± 6*20 ± 5*12 ± 5*8 ± 6
61% Sb + AOM7/7 (100)60 ± 13*25 ± 7*17 ± 8*9 ± 6*9 ± 5
7AOM + 0.033% Sb7/7 (100)120 ± 11*44 ± 4*48 ± 3*15 ± 3*13 ± 5
8AOM + 0.1% Sb7/7 (100)105 ± 8*44 ± 4*39 ± 5*12 ± 2*10 ± 2
9AOM + 0.33% Sb7/7 (100)89 ± 9*34 ± 3*30 ± 2*15 ± 2*10 ± 2
10AOM + 1% Sb7/7 (100)77 ± 8*29 ± 2*24 ± 3*13 ± 3*11 ± 2
11AOM + 0.032% sulindac6/6 (100)85 ± 7*32 ± 3*30 ± 2*14 ± 3*9 ± 2
121% Sb0/7 (0)

NOTE: Data are shown as mean ± SD of seven samples in each group (except groups 5 and 11, n = 6).

  • *P < 0.001, vs group 2 (Bonferroni t test).

  • P < 0.05.